Drug sensitivity prediction with normal inverse Gaussian shrinkage informed by external data.
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ABSTRACT:
SUBMITTER: Munch MM
PROVIDER: S-EPMC7891636 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Drug sensitivity prediction with normal inverse Gaussian shrinkage informed by external data.
Münch Magnus M MM van de Wiel Mark A MA Richardson Sylvia S Leday Gwenaël G R GGR
Biometrical journal. Biometrische Zeitschrift 20200723 2
In precision medicine, a common problem is drug sensitivity prediction from cancer tissue cell lines. These types of problems entail modelling multivariate drug responses on high-dimensional molecular feature sets in typically >1000 cell lines. The dimensions of the problem require specialised models and estimation methods. In addition, external information on both the drugs and the features is often available. We propose to model the drug responses through a linear regression with shrinkage enf ...[more]
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