Ontology highlight
ABSTRACT:
SUBMITTER: Morgan RK
PROVIDER: S-EPMC7891679 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Morgan Rory K RK Anderson Garret R GR Araç Demet D Aust Gabriela G Balenga Nariman N Boucard Antony A Bridges James P JP Engel Felix B FB Formstone Caroline J CJ Glitsch Maike D MD Gray Ryan S RS Hall Randy A RA Hsiao Cheng-Chih CC Kim Hee-Yong HY Knierim Alexander B AB Kusuluri Deva Krupakar DK Leon Katherine K Liebscher Ines I Piao Xianhua X Prömel Simone S Scholz Nicole N Srivastava Swati S Thor Doreen D Tolias Kimberley F KF Ushkaryov Yuri A YA Vallon Mario M Van Meir Erwin G EG Vanhollebeke Benoit B Wolfrum Uwe U Wright Kevin M KM Monk Kelly R KR Mogha Amit A
Annals of the New York Academy of Sciences 20190606 1
The adhesion class of G protein-coupled receptors (GPCRs) is the second largest family of GPCRs (33 members in humans). Adhesion GPCRs (aGPCRs) are defined by a large extracellular N-terminal region that is linked to a C-terminal seven transmembrane (7TM) domain via a GPCR-autoproteolysis inducing (GAIN) domain containing a GPCR proteolytic site (GPS). Most aGPCRs undergo autoproteolysis at the GPS motif, but the cleaved fragments stay closely associated, with the N-terminal fragment (NTF) bound ...[more]