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The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors.

ABSTRACT: The adhesion class of G protein-coupled receptors (GPCRs) is the second largest family of GPCRs (33 members in humans). Adhesion GPCRs (aGPCRs) are defined by a large extracellular N-terminal region that is linked to a C-terminal seven transmembrane (7TM) domain via a GPCR-autoproteolysis inducing (GAIN) domain containing a GPCR proteolytic site (GPS). Most aGPCRs undergo autoproteolysis at the GPS motif, but the cleaved fragments stay closely associated, with the N-terminal fragment (NTF) bound to the 7TM of the C-terminal fragment (CTF). The NTFs of most aGPCRs contain domains known to be involved in cell-cell adhesion, while the CTFs are involved in classical G protein signaling, as well as other intracellular signaling. In this workshop report, we review the most recent findings on the biology, signaling mechanisms, and physiological functions of aGPCRs.

SUBMITTER: Morgan RK 

PROVIDER: S-EPMC7891679 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors.

Morgan Rory K RK   Anderson Garret R GR   Araç Demet D   Aust Gabriela G   Balenga Nariman N   Boucard Antony A   Bridges James P JP   Engel Felix B FB   Formstone Caroline J CJ   Glitsch Maike D MD   Gray Ryan S RS   Hall Randy A RA   Hsiao Cheng-Chih CC   Kim Hee-Yong HY   Knierim Alexander B AB   Kusuluri Deva Krupakar DK   Leon Katherine K   Liebscher Ines I   Piao Xianhua X   Prömel Simone S   Scholz Nicole N   Srivastava Swati S   Thor Doreen D   Tolias Kimberley F KF   Ushkaryov Yuri A YA   Vallon Mario M   Van Meir Erwin G EG   Vanhollebeke Benoit B   Wolfrum Uwe U   Wright Kevin M KM   Monk Kelly R KR   Mogha Amit A  

Annals of the New York Academy of Sciences 20190606 1

The adhesion class of G protein-coupled receptors (GPCRs) is the second largest family of GPCRs (33 members in humans). Adhesion GPCRs (aGPCRs) are defined by a large extracellular N-terminal region that is linked to a C-terminal seven transmembrane (7TM) domain via a GPCR-autoproteolysis inducing (GAIN) domain containing a GPCR proteolytic site (GPS). Most aGPCRs undergo autoproteolysis at the GPS motif, but the cleaved fragments stay closely associated, with the N-terminal fragment (NTF) bound  ...[more]

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