Survival Analysis of Radiation Therapy in Ovarian Cancer: A SEER Database Analysis.
Ontology highlight
ABSTRACT: Results
A total of 20031 ovarian cancer patients were included, with 291 (1.45%) patients who received radiotherapy. The median overall survival (OS) in patients who received radiotherapy was shorter than which in patients without radiotherapy (23 vs. 75 months, P < 0.001). The Elderly, nonepithelial pathology, advanced American Joint Committee on Cancer (AJCC) stage, elevated level of CA125, and receiving radiotherapy were risk predictors to survival in both multivariable analyses before and after PSM. Among 11872 patients with III/IV stage, the radiotherapy group also showed a significantly worse prognosis (median OS: 19 vs. 44 months in patients without radiotherapy, P < 0.001). Consistent results were observed in stratification analyses on pathology and stage among patients with III/IV stage.Conclusions
For patients with ovarian cancer, radiotherapy was associated with a poor prognosis regardless of pathology or stage. Considering this is a retrospective study, future studies concerning radiotherapy combination with other new agents in ovarian cancer are needed.
SUBMITTER: Yu L
PROVIDER: S-EPMC7892241 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Survival Analysis of Radiation Therapy in Ovarian Cancer: A SEER Database Analysis.
Yu Lushi L Gong Hongyun H Li Qian Q Ren Honggang H Wang Yi Y He Haihua H Li Tian T Song Qibin Q
Journal of oncology 20210211
<h4>Results</h4>A total of 20031 ovarian cancer patients were included, with 291 (1.45%) patients who received radiotherapy. The median overall survival (OS) in patients who received radiotherapy was shorter than which in patients without radiotherapy (23 vs. 75 months, <i>P</i> < 0.001). The Elderly, nonepithelial pathology, advanced American Joint Committee on Cancer (AJCC) stage, elevated level of CA125, and receiving radiotherapy were risk predictors to survival in both multivariable analyse ...[more]
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