Ontology highlight
ABSTRACT:
SUBMITTER: Formaggio N
PROVIDER: S-EPMC7892335 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Formaggio Nicolò N Rubin Mark A MA Theurillat Jean-Philippe JP
Oncogene 20210108 7
Targeting the androgen receptor (AR) signaling axis has been, over decades, the mainstay of prostate cancer therapy. More potent inhibitors of androgen synthesis and antiandrogens have emerged and have been successfully implemented in clinical practice. That said, the stronger inhibition of the AR signaling axis has led in recent years to an increase of prostate cancers that de-differentiate into AR-negative disease. Unfortunately, this process is intimately linked with a poor prognosis. Here, w ...[more]