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Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro.

ABSTRACT: To identify drugs that are potentially used for the treatment of COVID-19, the potency of 1403 FDA-approved drugs were evaluated using a robust pseudovirus assay and the candidates were further confirmed by authentic SARS-CoV-2 assay. Four compounds, Clomiphene (citrate), Vortioxetine, Vortioxetine (hydrobromide) and Asenapine (hydrochloride), showed potent inhibitory effects in both pseudovirus and authentic virus assay. The combination of Clomiphene (citrate), Vortioxetine and Asenapine (hydrochloride) is much more potent than used alone, with IC50 of 0.34 ?M.

SUBMITTER: Xiong HL

PROVIDER: S-EPMC7892437 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro.

Xiong Hua-Long HL Cao Jia-Li JL Shen Chen-Guang CG Ma Jian J Qiao Xiao-Yang XY Shi Tian-Shu TS Ge Sheng-Xiang SX Ye Hui-Ming HM Zhang Jun J Yuan Quan Q Zhang Tian-Ying TY Xia Ning-Shao NS

Frontiers in pharmacology 20210205

To identify drugs that are potentially used for the treatment of COVID-19, the potency of 1403 FDA-approved drugs were evaluated using a robust pseudovirus assay and the candidates were further confirmed by authentic SARS-CoV-2 assay. Four compounds, Clomiphene (citrate), Vortioxetine, Vortioxetine (hydrobromide) and Asenapine (hydrochloride), showed potent inhibitory effects in both pseudovirus and authentic virus assay. The combination of Clomiphene (citrate), Vortioxetine and Asenapine (hydro ...[more]

PMID: 33613282

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