Unknown

Dataset Information

0

Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro.

ABSTRACT: To identify drugs that are potentially used for the treatment of COVID-19, the potency of 1403 FDA-approved drugs were evaluated using a robust pseudovirus assay and the candidates were further confirmed by authentic SARS-CoV-2 assay. Four compounds, Clomiphene (citrate), Vortioxetine, Vortioxetine (hydrobromide) and Asenapine (hydrochloride), showed potent inhibitory effects in both pseudovirus and authentic virus assay. The combination of Clomiphene (citrate), Vortioxetine and Asenapine (hydrochloride) is much more potent than used alone, with IC50 of 0.34 ?M.

SUBMITTER: Xiong HL 

PROVIDER: S-EPMC7892437 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro.

Xiong Hua-Long HL   Cao Jia-Li JL   Shen Chen-Guang CG   Ma Jian J   Qiao Xiao-Yang XY   Shi Tian-Shu TS   Ge Sheng-Xiang SX   Ye Hui-Ming HM   Zhang Jun J   Yuan Quan Q   Zhang Tian-Ying TY   Xia Ning-Shao NS  

Frontiers in pharmacology 20210205

To identify drugs that are potentially used for the treatment of COVID-19, the potency of 1403 FDA-approved drugs were evaluated using a robust pseudovirus assay and the candidates were further confirmed by authentic SARS-CoV-2 assay. Four compounds, Clomiphene (citrate), Vortioxetine, Vortioxetine (hydrobromide) and Asenapine (hydrochloride), showed potent inhibitory effects in both pseudovirus and authentic virus assay. The combination of Clomiphene (citrate), Vortioxetine and Asenapine (hydro  ...[more]

Similar Datasets

Unknown Computational Models Identify Several FDA Approved or Experimental Drugs as Putative Agents Against SARS-CoV-2.
| S-EPMC7252448 | biostudies-literature
Unknown Remdesivir and Ledipasvir among the FDA-Approved Antiviral Drugs Have Potential to Inhibit SARS-CoV-2 Replication.
| S-EPMC8146643 | biostudies-literature
Unknown Virtual screening FDA approved drugs against multiple targets of SARS-CoV-2.
| S-EPMC8014887 | biostudies-literature
Unknown Sulfated polysaccharides effectively inhibit SARS-CoV-2 in vitro.
| S-EPMC7378085 | biostudies-literature
Unknown Screening of FDA Approved Drugs Against SARS-CoV-2 Main Protease: Coronavirus Disease.
| S-EPMC7521772 | biostudies-literature
Unknown FDA approved drugs with pharmacotherapeutic potential for SARS-CoV-2 (COVID-19) therapy.
| S-EPMC7362818 | biostudies-literature
Unknown Insilico drug repurposing using FDA approved drugs against Membrane protein of SARS-CoV-2.
| S-EPMC7934671 | biostudies-literature
Unknown Hydroxypropyl Methylcellulose-Based Nasal Sprays Effectively Inhibit In Vitro SARS-CoV-2 Infection and Spread.
| S-EPMC8705245 | biostudies-literature
Unknown Host-Directed FDA-Approved Drugs with Antiviral Activity against SARS-CoV-2 Identified by Hierarchical In Silico/In Vitro Screening Methods.
| S-EPMC8067418 | biostudies-literature
Unknown FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection.
| S-EPMC3955358 | biostudies-literature