APOE and MAPT Are Associated With Dementia in Neuropathologically Confirmed Parkinson's Disease.

ABSTRACT: Introduction: Cognitive decline and dementia are common and debilitating non-motor phenotypic features of Parkinson's disease with a variable severity and time of onset. Common genetic variation of the Apolipoprotein E (APOE) and micro-tubule associated protein tau (MAPT) loci have been linked to cognitive decline and dementia in Parkinson's disease, although studies have yielded mixed results. To further elucidate the influence of APOE and MAPT variability on dementia in Parkinson's disease, we genotyped postmortem brain tissue samples of clinically and pathologically well-characterized Parkinson's donors and performed a survival analysis of time to dementia. Methods: We included a total of 152 neuropathologically confirmed Parkinson's disease don

SUBMITTER: Tunold JA 

PROVIDER: S-EPMC7892776 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature