Distinct lipid profile, low-level inflammation, and increased antioxidant defense signature in HIV-1 elite control status.
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ABSTRACT:
SUBMITTER: Sperk M
PROVIDER: S-EPMC7892918 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
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Distinct lipid profile, low-level inflammation, and increased antioxidant defense signature in HIV-1 elite control status.
Sperk Maike M Mikaeloff Flora F Svensson-Akusjärvi Sara S Krishnan Shuba S Ponnan Sivasankaran Munusamy SM Ambikan Anoop T AT Nowak Piotr P Sönnerborg Anders A Neogi Ujjwal U
iScience 20210128 2
HIV-1 elite controllers (EC) are a rare but heterogeneous group of HIV-1-infected individuals who can suppress viral replication in the absence of antiretroviral therapy. The mechanisms of how EC achieve undetectable viral loads remain unclear. This study aimed to investigate host plasma metabolomics and targeted plasma proteomics in a Swedish HIV-1 cohort including EC and treatment-naïve viremic progressors (VP) as well as HIV-negative individuals (HC) to get insights into EC phenotype. Metabol ...[more]
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