Ontology highlight
ABSTRACT:
SUBMITTER: Viana MP
PROVIDER: S-EPMC7892988 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Viana Martonio Ponte MP Levytskyy Roman M RM Anand Ruchika R Reichert Andreas S AS Khalimonchuk Oleh O
iScience 20210129 2
Remodeling of mitochondrial ultrastructure is a process that is critical for organelle physiology and apoptosis. Although the key players in this process-mitochondrial contact site and cristae junction organizing system (MICOS) and Optic Atrophy 1 (OPA1)-have been characterized, the mechanisms behind its regulation remain incompletely defined. Here, we found that in addition to its role in mitochondrial division, metallopeptidase OMA1 is required for the maintenance of intermembrane connectivity ...[more]