Dataset Information

One Health drivers of antibacterial resistance: Quantifying the relative impacts of human, animal and environmental use and transmission.

ABSTRACT:

Objectives

Antibacterial resistance (ABR) is a major global health security threat, with a disproportionate burden on lower-and middle-income countries (LMICs). It is not understood how 'One Health', where human health is co-dependent on animal health and the environment, might impact the burden of ABR in LMICs. Thailand's 2017 "National Strategic Plan on Antimicrobial Resistance" (NSP-AMR) aims to reduce AMR morbidity by 50% through 20% reductions in human and 30% in animal antibacterial use (ABU). There is a need to understand the implications of such a plan within a One Health perspective.

Methods

A model of ABU, gut colonisation with extended-spectrum beta-lactamase (ESBL)-producing bacteria and transmission was calibrated using estimates of the prevalence of ESBL-producing bacteria in Thailand. This model was used to project the reduction in human ABR over 20?years (2020-2040) for each One Health driver, including individual transmission rates between humans, animals and the environment, and to estimate the long-term impact of the NSP-AMR intervention.

Results

The model predicts that human ABU was the most important factor in reducing the colonisation of humans with resistant bacteria (maximum 65.7-99.7% reduction). The NSP-AMR is projected to reduce human colonisation by 6.0-18.8%, with more ambitious targets (30% reductions in human ABU) increasing this to 8.5-24.9%.

Conclusions

Our model provides a simple framework to explain the mechanisms underpinning ABR, suggesting that future interventions targeting the simultaneous reduction of transmission and ABU would help to control ABR more effectively in Thailand.

SUBMITTER: Booton RD

PROVIDER: S-EPMC7892992 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

One Health drivers of antibacterial resistance: Quantifying the relative impacts of human, animal and environmental use and transmission.

Booton Ross D RD Meeyai Aronrag A Alhusein Nour N Buller Henry H Feil Edward E Lambert Helen H Mongkolsuk Skorn S Pitchforth Emma E Reyher Kristen K KK Sakcamduang Walasinee W Satayavivad Jutamaad J Singer Andrew C AC Sringernyuang Luechai L Thamlikitkul Visanu V Vass Lucy L Avison Matthew B MB Turner Katherine M E KME

One health (Amsterdam, Netherlands) 20210126

<h4>Objectives</h4>Antibacterial resistance (ABR) is a major global health security threat, with a disproportionate burden on lower-and middle-income countries (LMICs). It is not understood how 'One Health', where human health is co-dependent on animal health and the environment, might impact the burden of ABR in LMICs. Thailand's 2017 "National Strategic Plan on Antimicrobial Resistance" (NSP-AMR) aims to reduce AMR morbidity by 50% through 20% reductions in human and 30% in animal antibacteria ...[more]

PMID: 33644290

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Dataset Information

One Health drivers of antibacterial resistance: Quantifying the relative impacts of human, animal and environmental use and transmission.

Objectives

Methods

Results

Conclusions

Publications

One Health drivers of antibacterial resistance: Quantifying the relative impacts of human, animal and environmental use and transmission.

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