Highly active alkyne metathesis catalysts operating under open air condition.

ABSTRACT: Alkyne metathesis represents a rapidly emerging synthetic method that has shown great potential in small molecule and polymer synthesis. However, its practical use has been impeded by the limited availability of user-friendly catalysts and their generally high moisture/air sensitivity. Herein, we report an alkyne metathesis catalyst system that can operate under open-air conditions with a broad substrate scope and excellent yields. These catalysts are composed of simple multidentate tris(2-hydroxyphenyl)methane ligands, which can be easily prepared in multi-gram scale. The catalyst substituted with electron withdrawing cyano groups exhibits the highest activity at room temperature with excellent functional group tolerance (-OH, -CHO, -NO₂, pyridyl). More importantly, the catalys

SUBMITTER: Ge Y 

PROVIDER: S-EPMC7893043 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature