(-)-Epigallocatechin-3-gallate Inhibits Human and Rat Renal Organic Anion Transporters.
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ABSTRACT:
SUBMITTER: Kawasaki T
PROVIDER: S-EPMC7893792 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
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(-)-Epigallocatechin-3-gallate Inhibits Human and Rat Renal Organic Anion Transporters.
Kawasaki Tatsuya T Kondo Masaki M Hiramatsu Rioka R Nabekura Tomohiro T
ACS omega 20210202 6
Organic anion transporter 1 (OAT1, <i>SLC22A6</i>) and 3 (OAT3, <i>SLC22A8</i>) are multispecific drug transporters highly expressed on the basolateral membranes of the renal proximal tubules. OAT1 and OAT3 mediate the tubular secretion of clinically significant drugs; thus, they influence the pharmacokinetics of drugs and further determine their efficacy and toxicity. OAT1 and OAT3 are also the target of drug-drug interactions. In this study, we examined the effects of the tea catechin (-)-epig ...[more]
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