Ontology highlight
ABSTRACT: Background
The management of unresectable locally advanced colon cancer (LACC) remains controversial, as resection is not feasible. The goal of this study was to evaluate the treatment outcomes and toxicity of neoadjuvant chemoradiotherapy (NACRT) followed with surgery and adjuvant chemotherapy in patients with unresectable radically LACC.Methods
We included patients who were diagnosed at our institution, 2010-2018. The neoadjuvant regimen consisted of radiotherapy and capecitabine/ 5-fluorouracil-based chemotherapy.Results
One hundred patients were identified. The median follow-up time was 32?months. The R0 resection rate, adjusted nonmultivisceral resection rate and bladder preservation rate were 83.0, 43.0 and 83.3%, respectively. The pCR and clinical-downstaging rates were 18, and 81.0%%, respectively. The 3-year PFS and OS rates for all patients were 68.6 and 82.1%, respectively. Seventeen patients developed grade 3-4 myelosuppression, which was the most common adverse event observed after NACRT. Tumor perforation occurred in 3 patients during NACRT. The incidence of grade 3-4 surgery-related complications was 7.0%. Postoperative anastomotic leakage was observed in 3 patients.Conclusions
NACRT followed by surgery was feasible and safe for selected patients with LACC, and can be used as a conversion treatment to achieve satisfactory downstaging, long-term survival and quality of life, with acceptable toxicities.
SUBMITTER: Yuan Y
PROVIDER: S-EPMC7893883 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Yuan Yan Y Xiao Wei-Wei WW Xie Wei-Hao WH Cai Pei-Qiang PQ Wang Qiao-Xuan QX Chang Hui H Chen Bao-Qing BQ Zhou Wen-Hao WH Zeng Zhi-Fan ZF Wu Xiao-Jun XJ Liu Qing Q Li Li-Ren LR Zhang Rong R Gao Yuan-Hong YH
BMC cancer 20210219 1
<h4>Background</h4>The management of unresectable locally advanced colon cancer (LACC) remains controversial, as resection is not feasible. The goal of this study was to evaluate the treatment outcomes and toxicity of neoadjuvant chemoradiotherapy (NACRT) followed with surgery and adjuvant chemotherapy in patients with unresectable radically LACC.<h4>Methods</h4>We included patients who were diagnosed at our institution, 2010-2018. The neoadjuvant regimen consisted of radiotherapy and capecitabi ...[more]