Dataset Information

Development of genome-wide polygenic risk scores for lipid traits and clinical applications for dyslipidemia, subclinical atherosclerosis, and diabetes cardiovascular complications among East Asians.

ABSTRACT:

Background

The clinical utility of personal genomic information in identifying individuals at increased risks for dyslipidemia and cardiovascular diseases remains unclear.

Methods

We used data from Biobank Japan (n?=?70,657-128,305) and developed novel East Asian-specific genome-wide polygenic risk scores (PRSs) for four lipid traits. We validated (n?=?4271) and subsequently tested associations of these scores with 3-year lipid changes in adolescents (n?=?620), carotid intima-media thickness (cIMT) in adult women (n?=?781), dyslipidemia (n?=?7723), and coronary heart disease (CHD) (n?=?2374 cases and 6246 controls) in type 2 diabetes (T2D) patients.

Results

Our PRSs aggregating 84-549 genetic variants (0.251?-?103?-?75) and 3-year lipid changes (1.4?×?10^-?6?-?3?-?10?trend?=?0.0182). Independent of conventional risk factors, the quintile of PRSs for TC [OR (95% CI)?=?1.07 (1.03-1.11)], TG [OR (95% CI)?=?1.05 (1.01-1.09)], and LDL-C [OR (95% CI)?=?1.05 (1.01-1.09)] were significantly associated with increased risk of CHD in T2D patients (4.8?×?10^-?4?ConclusionsThe PRSs derived and validated here highlight the potential for early genomic screening and personalized risk assessment for cardiovascular disease.

SUBMITTER: Tam CHT

PROVIDER: S-EPMC7893928 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Publications

Development of genome-wide polygenic risk scores for lipid traits and clinical applications for dyslipidemia, subclinical atherosclerosis, and diabetes cardiovascular complications among East Asians.

Tam Claudia H T CHT Lim Cadmon K P CKP Luk Andrea O Y AOY Ng Alex C W ACW Lee Heung-Man HM Jiang Guozhi G Lau Eric S H ESH Fan Baoqi B Wan Raymond R Kong Alice P S APS Tam Wing-Hung WH Ozaki Risa R Chow Elaine Y K EYK Lee Ka-Fai KF Siu Shing-Chung SC Hui Grace G Tsang Chiu-Chi CC Lau Kam-Piu KP Leung Jenny Y Y JYY Tsang Man-Wo MW Kam Grace G Lau Ip-Tim IT Li June K Y JKY Yeung Vincent T F VTF Lau Emmy E Lo Stanley S Fung Samuel S Cheng Yuk-Lun YL Chow Chun-Chung CC Hu Miao M Yu Weichuan W Tsui Stephen K W SKW Huang Yu Y Lan Huiyao H Szeto Cheuk-Chun CC Tang Nelson L S NLS Ng Maggie C Y MCY So Wing-Yee WY Tomlinson Brian B Chan Juliana C N JCN Ma Ronald C W RCW

Genome medicine 20210219 1

<h4>Background</h4>The clinical utility of personal genomic information in identifying individuals at increased risks for dyslipidemia and cardiovascular diseases remains unclear.<h4>Methods</h4>We used data from Biobank Japan (n = 70,657-128,305) and developed novel East Asian-specific genome-wide polygenic risk scores (PRSs) for four lipid traits. We validated (n = 4271) and subsequently tested associations of these scores with 3-year lipid changes in adolescents (n = 620), carotid intima-medi ...[more]

PMID: 33608049

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Dataset Information

Development of genome-wide polygenic risk scores for lipid traits and clinical applications for dyslipidemia, subclinical atherosclerosis, and diabetes cardiovascular complications among East Asians.

Background

Methods

Results

Publications

Development of genome-wide polygenic risk scores for lipid traits and clinical applications for dyslipidemia, subclinical atherosclerosis, and diabetes cardiovascular complications among East Asians.

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