Ontology highlight
ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC7893957 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Zhang Lina L Wang Shuai S Xu Ji J Zhang Run R Zhu Han H Wu Yujie Y Zhu Liying L Li Jianyong J Chen Lijuan L
Experimental hematology & oncology 20210219 1
Cytokine release syndrome (CRS) is the most common toxicity induced by chimeric antigen receptor (CAR) T cell therapy. At present, anti-IL-6 agents including tocilizumab and siltuximab have been applied in the treatment of CRS. However, tocilizumab and siltuximab are expensive and some patients fail to respond to anti-IL-6 therapy, which urges the need for new drugs. In clinical practice, we found some patients with multiple myeloma developed markedly increased levels of tumor necrosis factor (T ...[more]