Ontology highlight
ABSTRACT:
SUBMITTER: Saito T
PROVIDER: S-EPMC7894003 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Saito Takuma T Tsukahara Tomohide T Suzuki Takeshi T Nojima Iyori I Tadano Hiroki H Kawai Noriko N Kubo Terufumi T Hirohashi Yoshihiko Y Kanaseki Takayuki T Torigoe Toshihiko T Li Liming L
Cancer science 20201204 2
Photodynamic therapy (PDT) using the photosensitizer talaporfin sodium (talaporfin) is a new mode of treatment for cancer. However, the metabolic mechanism of talaporfin has not been clarified. Thus, we investigated the uptake, transportation, and elimination mechanisms of talaporfin in carcinoma and sarcoma. The results showed that talaporfin co-localized in early endosomes and lysosomes. Talaporfin uptake was via clathrin- and caveolae-dependent endocytosis and a high amount of intracellular A ...[more]