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Intracellular localization of CK2? as a prognostic factor in invasive breast carcinomas.

ABSTRACT: Overexpression of the ubiquitous protein kinase, CK2?, has been reported in various human cancers. Here, we demonstrate that nuclear and nucleolar CK2? localization in invasive ductal carcinomas of the breast is a reliable predictor of poor prognosis. Cellular localization of CK2? in nuclei and nucleoli was analyzed immunohistochemically using surgical tissue blocks from 112 patients, who had undergone surgery without neoadjuvant chemotherapy. Clinical data collection and median follow-up period were for more than 5 y. In total, 93.8% of patients demonstrated elevated CK2? expression in nuclei and 36.6% of them displayed elevated expression predominantly in nucleoli. Clinicopathological malignancy was strongly correlated with elevated nuclear and nucleolar CK2? expression. Recurrence-free survival was significantly worse (P = .0002) in patients with positive nucleolar CK2? staining. The 5-y survival rate decreased to a roughly 50% in nucleolar CK2?-positive patients of triple-negative (P = .0069) and p Stage 3 (P = .0073) groups. In contrast, no patients relapsed or died in the triple-negative group who exhibited a lack of nucleolar CK2? staining. Evaluation of nucleolar CK2? staining showed a high secondary index with a hazard ratio of 6.629 (P = .001), following lymph node metastasis with a hazard ratio of 14.30 (P = .0008). Multivariate analysis demonstrated that nucleolar CK2? is an independent factor for recurrence-free survival. Therefore, we propose that histochemical evaluation of nucleolar CK2?-positive staining may be a new and robust prognostic indicator for patients who need further treatment. Functional consequences of nucleolar CK2 dysfunction may be a starting point to facilitate development of novel treatments for invasive breast carcinoma.

SUBMITTER: Homma MK

PROVIDER: S-EPMC7894005 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Intracellular localization of CK2α as a prognostic factor in invasive breast carcinomas.

Homma Miwako Kato MK Kiko Yuichiro Y Hashimoto Yuko Y Nagatsuka Miki M Katagata Naoto N Masui Seiichiro S Homma Yoshimi Y Nomizu Tadashi T

Cancer science 20210113 2

Overexpression of the ubiquitous protein kinase, CK2α, has been reported in various human cancers. Here, we demonstrate that nuclear and nucleolar CK2α localization in invasive ductal carcinomas of the breast is a reliable predictor of poor prognosis. Cellular localization of CK2α in nuclei and nucleoli was analyzed immunohistochemically using surgical tissue blocks from 112 patients, who had undergone surgery without neoadjuvant chemotherapy. Clinical data collection and median follow-up period ...[more]

PMID: 33164285

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Dataset Information

Intracellular localization of CK2? as a prognostic factor in invasive breast carcinomas.

Publications

Intracellular localization of CK2α as a prognostic factor in invasive breast carcinomas.

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