Dataset Information

Whole-Volume Tumor MRI Radiomics for Prognostic Modeling in Endometrial Cancer.

ABSTRACT:

Background

In endometrial cancer (EC), preoperative pelvic MRI is recommended for local staging, while final tumor stage and grade are established by surgery and pathology. MRI-based radiomic tumor profiling may aid in preoperative risk-stratification and support clinical treatment decisions in EC.

Purpose

To develop MRI-based whole-volume tumor radiomic signatures for prediction of aggressive EC disease.

Study type

Retrospective.

Population

A total of 138 women with histologically confirmed EC, divided into training (n_T = 108) and validation cohorts (n_V = 30).

Field strength/sequence

Axial oblique T₁ -weighted gradient echo volumetric interpolated breath-hold examination (VIBE) at 1.5T (71/138 patients) and DIXON VIBE at 3T (67/138 patients) at 2?minutes postcontrast injection.

Assessment

Primary tumors were manually segmented by two radiologists with 4 and 8?years' of experience. Radiomic tumor features were computed and used for prediction of surgicopathologically-verified deep (?50%) myometrial invasion (DMI), lymph node metastases (LNM), advanced stage (FIGO III?+?IV), nonendometrioid (NE) histology, and high-grade endometrioid tumors (E3). Corresponding analyses were also conducted using radiomics extracted from the axial oblique image slice depicting the largest tumor area.

Statistical tests

Logistic least absolute shrinkage and selection operator (LASSO) was applied for radiomic modeling in the training cohort. The diagnostic performances of the radiomic signatures were evaluated by area under the receiver operating characteristic curve in the training (AUC_T ) and validation (AUC_V ) cohorts. Progression-free survival was assessed using the Kaplan-Meier and Cox proportional hazard model.

Results

The whole-tumor radiomic signatures yielded AUC_T /AUC_V of 0.84/0.76 for predicting DMI, 0.73/0.72 for LNM, 0.71/0.68 for FIGO III?+?IV, 0.68/0.74 for NE histology, and 0.79/0.63 for high-grade (E3) tumor. Single-slice radiomics yielded comparable AUC_T but significantly lower AUC_V for LNM and FIGO III?+?IV (both P?T to the whole-tumor radiomic signatures for prediction of DMI, LNM, FIGO III?+?IV, and NE, but significantly lower AUC_T for E3 tumors (P?Data conclusionMRI-based whole-tumor radiomic signatures yield medium-to-high diagnostic performance for predicting aggressive EC disease. The signatures may aid in preoperative risk assessment and hence guide personalized treatment strategies in EC.

Level of evidence

4 TECHNICAL EFFICACY STAGE: 2.

SUBMITTER: Fasmer KE

PROVIDER: S-EPMC7894560 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Publications

Whole-Volume Tumor MRI Radiomics for Prognostic Modeling in Endometrial Cancer.

Fasmer Kristine E KE Hodneland Erlend E Dybvik Julie A JA Wagner-Larsen Kari K Trovik Jone J Salvesen Øyvind Ø Krakstad Camilla C Haldorsen Ingfrid H S IHS

Journal of magnetic resonance imaging : JMRI 20201116 3

<h4>Background</h4>In endometrial cancer (EC), preoperative pelvic MRI is recommended for local staging, while final tumor stage and grade are established by surgery and pathology. MRI-based radiomic tumor profiling may aid in preoperative risk-stratification and support clinical treatment decisions in EC.<h4>Purpose</h4>To develop MRI-based whole-volume tumor radiomic signatures for prediction of aggressive EC disease.<h4>Study type</h4>Retrospective.<h4>Population</h4>A total of 138 women with ...[more]

PMID: 33200420

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Dataset Information

Whole-Volume Tumor MRI Radiomics for Prognostic Modeling in Endometrial Cancer.

Background

Purpose

Study type

Population

Field strength/sequence

Assessment

Statistical tests

Results

Level of evidence

Publications

Whole-Volume Tumor MRI Radiomics for Prognostic Modeling in Endometrial Cancer.

Similar Datasets

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