A comparison of methods to generate adaptive reference ranges in longitudinal monitoring.
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ABSTRACT:
SUBMITTER: Roshan D
PROVIDER: S-EPMC7894906 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
A comparison of methods to generate adaptive reference ranges in longitudinal monitoring.
Roshan Davood D Ferguson John J Pedlar Charles R CR Simpkin Andrew A Wyns William W Sullivan Frank F Newell John J
PloS one 20210219 2
In a clinical setting, biomarkers are typically measured and evaluated as biological indicators of a physiological state. Population based reference ranges, known as 'static' or 'normal' reference ranges, are often used as a tool to classify a biomarker value for an individual as typical or atypical. However, these ranges may not be informative to a particular individual when considering changes in a biomarker over time since each observation is assessed in isolation and against the same referen ...[more]
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