Ontology highlight
ABSTRACT:
SUBMITTER: Weigand I
PROVIDER: S-EPMC7895437 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Science advances 20210219 8
Mutations in the <i>PRKACA</i> gene are the most frequent cause of cortisol-producing adrenocortical adenomas leading to Cushing's syndrome. <i>PRKACA</i> encodes for the catalytic subunit α of protein kinase A (PKA). We already showed that <i>PRKACA</i> mutations lead to impairment of regulatory (R) subunit binding. Furthermore, <i>PRKACA</i> mutations are associated with reduced RIIβ protein levels; however, the mechanisms leading to reduced RIIβ levels are presently unknown. Here, we investig ...[more]