Ontology highlight
ABSTRACT:
SUBMITTER: Drake RA
PROVIDER: S-EPMC7895525 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
eLife 20210208
The loss of descending inhibitory control is thought critical to the development of chronic pain but what causes this loss in function is not well understood. We have investigated the dynamic contribution of prelimbic cortical neuronal projections to the periaqueductal grey (PrL-P) to the development of neuropathic pain in rats using combined opto- and chemogenetic approaches. We found PrL-P neurons to exert a tonic inhibitory control on thermal withdrawal thresholds in uninjured animals. Follow ...[more]