Ontology highlight
ABSTRACT:
SUBMITTER: Tokamov SA
PROVIDER: S-EPMC7895526 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Tokamov Sherzod A SA Su Ting T Ullyot Anne A Fehon Richard G RG
eLife 20210208
The Hippo (Hpo) pathway regulates tissue growth in many animals. Multiple upstream components promote Hpo pathway activity, but the organization of these different inputs, the degree of crosstalk between them, and whether they are regulated in a distinct manner is not well understood. Kibra (Kib) activates the Hpo pathway by recruiting the core Hpo kinase cassette to the apical cortex. Here, we show that the Hpo pathway downregulates <i>Drosophila</i> Kib levels independently of Yorkie-mediated ...[more]