Hepcidin-Mediated Hypoferremia Disrupts Immune Responses to Vaccination and Infection.

ABSTRACT:

Background

How specific nutrients influence adaptive immunity is of broad interest. Iron deficiency is the most common micronutrient deficiency worldwide and imparts a significant burden of global disease; however, its effects on immunity remain unclear.

Methods

We used a hepcidin mimetic and several genetic models to examine the effect of low iron availability on T cells in vitro and on immune responses to vaccines and viral infection in mice. We examined humoral immunity in human patients with raised hepcidin and low serum iron caused by mutant TMPRSS6. We tested the effect of iron supplementation on vaccination-induced humoral immunity in piglets, a natural model of iron deficiency.

Findings

We show that low serum iron (hypoferremia), caused by increa

SUBMITTER: Frost JN 

PROVIDER: S-EPMC7895906 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature