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Long-term exposure to a hypomagnetic field attenuates adult hippocampal neurogenesis and cognition.

ABSTRACT: Adult hippocampal neurogenesis contributes to learning and memory, and is sensitive to a variety of environmental stimuli. Exposure to a hypomagnetic field (HMF) influences the cognitive processes of various animals, from insects to human beings. However, whether HMF exposure affect adult hippocampal neurogenesis and hippocampus-dependent cognitions is still an enigma. Here, we showed that male C57BL/6?J mice exposed to HMF by means of near elimination of the geomagnetic field (GMF) exhibit significant impairments of adult hippocampal neurogenesis and hippocampus-dependent learning, which is strongly correlated with a reduction in the content of reactive oxygen species (ROS). However, these deficits seen in HMF-exposed mice could be rescued either by elevating ROS levels through pharmacological inhibition of ROS removal or by returning them back to GMF. Therefore, our results suggest that GMF plays an important role in adult hippocampal neurogenesis through maintaining appropriate endogenous ROS levels.

SUBMITTER: Zhang B

PROVIDER: S-EPMC7896063 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Long-term exposure to a hypomagnetic field attenuates adult hippocampal neurogenesis and cognition.

Zhang Bingfang B Wang Lei L Zhan Aisheng A Wang Min M Tian Lanxiang L Guo Weixiang W Pan Yongxin Y

Nature communications 20210219 1

Adult hippocampal neurogenesis contributes to learning and memory, and is sensitive to a variety of environmental stimuli. Exposure to a hypomagnetic field (HMF) influences the cognitive processes of various animals, from insects to human beings. However, whether HMF exposure affect adult hippocampal neurogenesis and hippocampus-dependent cognitions is still an enigma. Here, we showed that male C57BL/6 J mice exposed to HMF by means of near elimination of the geomagnetic field (GMF) exhibit sign ...[more]

PMID: 33608552

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Long-term exposure to a hypomagnetic field attenuates adult hippocampal neurogenesis and cognition.

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Long-term exposure to a hypomagnetic field attenuates adult hippocampal neurogenesis and cognition.

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