Dataset Information

Association between fluoroquinolone resistance and MRSA genotype in Alexandria, Egypt.

ABSTRACT: Antimicrobial stewardship isn't strictly observed in most Egyptian hospitals, raising antibiotic resistance. Epidemiology of Egyptian MRSA isolates, or associations with resistance to other antibiotics remain largely unknown. We identified MRSA genotypes in Alexandria Main University Hospital (AMUH) and investigated rates of moxifloxacin resistance, an alternative MRSA treatment, among different genotypes. Antibiotic susceptibility of 72 MRSA clinical isolates collected in 2015 from AMUH was determined by disc diffusion and broth microdilution. spa- and Staphylococcal Cassette Chromosome mec (SCCmec) typing were performed; with multi-locus sequence typing conducted on isolates representing major genotypes. Resistance to moxifloxacin, levofloxacin and ciprofloxacin were 69%, 78% and 96%, respectively. spa type t037 (57%) was commonest, followed by t127 (12.5%), t267 (8%) and t688 (6%). SCCmec III predominated (57%), all of these were moxifloxacin resistant and 97.6% t037 (ST241). SCCmec IV, IV E and V represented 15%, 7% and 11% of the isolates, respectively, 79% of these were moxifloxacin susceptible and of different spa types. t127 (ST-1) was associated with SCCmec V in 56% of the isolates, mostly moxifloxacin susceptible. Moxifloxacin resistance was high, most resistant isolates belonged to t037 and SCCmec III, suggesting local dissemination and antibiotic pressure. We recommend caution in treating MRSA infections with moxifloxacin.

SUBMITTER: Alseqely M

PROVIDER: S-EPMC7896087 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Association between fluoroquinolone resistance and MRSA genotype in Alexandria, Egypt.

Alseqely Mustafa M Newton-Foot Mae M Khalil Amal A El-Nakeeb Mostafa M Whitelaw Andrew A Abouelfetouh Alaa A

Scientific reports 20210219 1

Antimicrobial stewardship isn't strictly observed in most Egyptian hospitals, raising antibiotic resistance. Epidemiology of Egyptian MRSA isolates, or associations with resistance to other antibiotics remain largely unknown. We identified MRSA genotypes in Alexandria Main University Hospital (AMUH) and investigated rates of moxifloxacin resistance, an alternative MRSA treatment, among different genotypes. Antibiotic susceptibility of 72 MRSA clinical isolates collected in 2015 from AMUH was det ...[more]

PMID: 33608606

Similar Datasets

Project description:BackgroundFood labeling is an important public health tool allowing consumers to make informed and healthy choices. Considering how important it is for consumers to be aware of food labels while choosing healthy foods, this study aims at assessing public awareness, attitude, and practice regarding food labeling in Alexandria Governorate, Egypt.MethodsA cross sectional study using a predesigned interview questionnaire to collect data from 719 adult consumers from both sexes (28.2% males: 71.8% females), recruited from different branches of one of the largest supermarkets in Alexandria.ResultsMore than half of the participants (55.6%) reported reading food labels. The most frequently read information was production/ expiry date (76.8%), product name (68.3%), and ingredients (38.0%) while the least frequently read was nutritional facts (29.9%). More than half of the study sample (50.9%) had low awareness about the content of food labels, nevertheless, having higher scores on awareness about food labels predicted reading practice. Nearly three-quarters of the respondents had average to good food label reading practice. Most respondents (81.8%) had a favorable attitude about food labeling in its present form, however, higher attitude scores did not seem to influence their use of food labels. Being older (β = 0.045, CI; 0.014-0.076, p = 0.005), being female (β = 1.162, CI; 0.541-1.784, p = 0.000), having secondary education or equivalent (β = 1.042,CI; 0.050-2.034, p = 0.040), having university education or beyond (β = 3.090, CI; 2.132-4.048, p = 0.000), and having higher scores on awareness about food labels (β = 1.407, CI; 1.324-1.490, p = 0.000) were significant predictors of reading food labels.ConclusionsMost of the studied consumers had a positive attitude towards food labeling, however, more than half of them had low awareness of food labeling content. Nutritional facts were the least frequently read by consumers. Reading food labels was significantly predicted by having higher education, being older, being a female, and having better awareness.

Project description:BackgroundThe green building industry has significantly impacted the construction market, providing various sustainable solutions for the community. However, conventional green building standards have yet to adequately address occupant health and well-being, leading to challenges with performance. This has caused many businesses to take note of the latest report from the Bureau of Labour Statistics, which indicated that productivity in the US has dropped by the sharpest level since the 1940s. 1 Addressing these issues, organisations like International WELL Building Institute (IWBI) developed WELL Building Rating System (WELL), prioritising occupant health and well-being as critical components for improving performance and avoiding potential vulnerabilities brought about by sickness or pandemics. For this reason, this study will explore how to improve employee productivity within office buildings by bettering their overall health and well-being.MethodsA comprehensive data collection approach was employed in this paper, involving the analysis of office form evolution, and the evaluation of productivity attributes in office spaces. Resulting in identifying the top design-oriented features impacting employee productivity. Data was gathered from traditional office designs, trending successful office buildings, and the WELL Building Rating System to understand the concept of healthy building design.ResultsShowing thermal comfort, ventilation, and natural daylight significantly influence employees' productivity. Implementing conducted design features from WELL achieved an average of 20.2%-35.6% decrease in thermal gain throughout the year, a 20% increase in airflow, an average 2.4%-6.5% decrease in Air temperature, enhanced temperature distribution by 7%, and direct sunlight minimum reduction by 9% in Winter and maximum 21.9% in Spring.ConclusionNew design features in trending successful office buildings positively impact employee productivity. Particularly the outlined features by WELL Building Rating System led to identifying the most influential factors affecting occupant productivity. The results of this study informed recommendations for enhancing productivity in existing office buildings in Alexandria, Egypt.

Dataset Information

Association between fluoroquinolone resistance and MRSA genotype in Alexandria, Egypt.

Publications

Association between fluoroquinolone resistance and MRSA genotype in Alexandria, Egypt.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets