Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez-Costa C
PROVIDER: S-EPMC7896416 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Fernández-Costa Carolina C Martínez-Bartolomé Salvador S McClatchy Daniel D Yates John R JR
Analytical chemistry 20200109 2
Mass spectrometry-based proteomics is an invaluable tool for addressing important biological questions. Data-dependent acquisition methods effectuate stochastic acquisition of data in complex mixtures, which results in missing identifications across replicates. We developed a search approach that improves the reproducibility of data acquired from any mass spectrometer. In our approach, a spectral library is built from the identification results from a database search, and then, the library is us ...[more]