Ontology highlight
ABSTRACT:
SUBMITTER: Shan CM
PROVIDER: S-EPMC7896557 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Cell reports 20201201 13
One key aspect of epigenetic inheritance is that chromatin structures can be stably inherited through generations after the removal of the signals that establish such structures. In fission yeast, the RNA interference (RNAi) pathway is critical for the targeting of histone methyltransferase Clr4 to pericentric repeats to establish heterochromatin. However, pericentric heterochromatin cannot be properly inherited in the absence of RNAi, suggesting the existence of mechanisms that counteract chrom ...[more]