Quantitative T1 mapping of the normal brain from early infancy to adulthood.
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ABSTRACT: Background
Quantitative mapping of MRI relaxation times is expected to uncover pathological processes in the brain more subtly than standard MRI techniques with weighted contrasts. So far, however, most mapping techniques suffer from a long measuring time, low spatial resolution or even sensitivity to magnetic field inhomogeneity.Objective
To obtain T1 relaxation times of the normal brain from early infancy to adulthood using a novel technique for fast and accurate T1 mapping at high spatial resolution.Materials and methods
We performed whole-brain T1 mapping within less than 3 min in 100 patients between 2 months and 18 years of age with normal brain at a field strength of 3 T. We analyzed T1 relaxation times in several gray-matter nuclei and white matter. Subsequently, we derived regression equations for mean value and confidence interval.Results
T1 relaxation times of the pediatric brain rapidly decrease in all regions within the first 3 years of age, followed by a significantly weaker decrease until adulthood. These characteristics are more pronounced in white matter than in deep gray matter.Conclusion
Regardless of age, quantitative T1 mapping of the pediatric brain is feasible in clinical practice. Normal age-dependent values should contribute to improved discrimination of subtle intracerebral alterations.
SUBMITTER: Grafe D
PROVIDER: S-EPMC7897197 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Quantitative T1 mapping of the normal brain from early infancy to adulthood.
Gräfe Daniel D Frahm Jens J Merkenschlager Andreas A Voit Dirk D Hirsch Franz Wolfgang FW
Pediatric radiology 20201017 3
<h4>Background</h4>Quantitative mapping of MRI relaxation times is expected to uncover pathological processes in the brain more subtly than standard MRI techniques with weighted contrasts. So far, however, most mapping techniques suffer from a long measuring time, low spatial resolution or even sensitivity to magnetic field inhomogeneity.<h4>Objective</h4>To obtain T1 relaxation times of the normal brain from early infancy to adulthood using a novel technique for fast and accurate T1 mapping at ...[more]
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