Ontology highlight
ABSTRACT:
SUBMITTER: Nakao Y
PROVIDER: S-EPMC7897289 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Nakao Yuki Y Fukuda Takao T Zhang Qunzhou Q Sanui Terukazu T Shinjo Takanori T Kou Xiaoxing X Chen Chider C Liu Dawei D Watanabe Yukari Y Hayashi Chikako C Yamato Hiroaki H Yotsumoto Karen K Tanaka Urara U Taketomi Takaharu T Uchiumi Takeshi T Le Anh D AD Shi Songtao S Nishimura Fusanori F
Acta biomaterialia 20201224
Mesenchymal stem cell (MSC)-derived exosome plays a central role in the cell-free therapeutics involving MSCs and the contents can be customized under disease-associated microenvironments. However, optimal MSC-preconditioning to enhance its therapeutic potential is largely unknown. Here, we show that preconditioning of gingival tissue-derived MSCs (GMSCs) with tumor necrosis factor-alpha (TNF-α) is ideal for the treatment of periodontitis. TNF-α stimulation not only increased the amount of exoso ...[more]