Ontology highlight
ABSTRACT:
SUBMITTER: Asahina M
PROVIDER: S-EPMC7897899 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Asahina Makoto M Fujinawa Reiko R Fujihira Haruhiko H Masahara-Negishi Yuki Y Andou Tomohiro T Tozawa Ryuichi R Suzuki Tadashi T
Proceedings of the Japan Academy. Series B, Physical and biological sciences 20210101 2
N-Glycanase 1 (NGLY1) deficiency is a congenital disorder caused by mutations in the NGLY1 gene. Because systemic Ngly1<sup>-/-</sup> mice with a C57BL/6 (B6) background are embryonically lethal, studies on the mechanism of NGLY1 deficiency using mice have been problematic. In this study, B6-Ngly1<sup>-/+</sup> mice were crossed with Japanese wild mice-originated Japanese fancy mouse 1 (JF1) mice to produce viable F<sub>2</sub> Ngly1<sup>-/-</sup> mice from (JF1×B6)F<sub>1</sub> Ngly1<sup>-/+</s ...[more]