Evidence for the loss and recovery of SLAMF9 during human evolution: implications on Dollo's law.
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ABSTRACT:
SUBMITTER: Murphy MK
PROVIDER: S-EPMC7898023 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Evidence for the loss and recovery of SLAMF9 during human evolution: implications on Dollo's law.
Murphy Maegan K MK Moon Justin T JT Skolaris Alexis T AT Mikulin Joseph A JA Wilson Timothy J TJ
Immunogenetics 20210222 3
Signaling lymphocyte activation molecule family member 9 (SLAMF9) is a cell surface protein of the CD2/SLAM family of leukocyte surface receptors. It is conserved throughout mammals and has roles in the initiation of inflammatory responses and regulation of plasmacytoid dendritic cell function. Through comparison of reference sequences encoding SLAMF9 in human, mouse, and primate sequences, we have determined that the SLAMF9 gene underwent successive mutation events, resulting in the loss of the ...[more]
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