Sex Differences in Gene Expression and Regulatory Networks across 29 Human Tissues.
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ABSTRACT:
SUBMITTER: Lopes-Ramos CM
PROVIDER: S-EPMC7898458 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Sex Differences in Gene Expression and Regulatory Networks across 29 Human Tissues.
Lopes-Ramos Camila M CM Chen Cho-Yi CY Kuijjer Marieke L ML Paulson Joseph N JN Sonawane Abhijeet R AR Fagny Maud M Platig John J Glass Kimberly K Quackenbush John J DeMeo Dawn L DL
Cell reports 20200601 12
Sex differences manifest in many diseases and may drive sex-specific therapeutic responses. To understand the molecular basis of sex differences, we evaluated sex-biased gene regulation by constructing sample-specific gene regulatory networks in 29 human healthy tissues using 8,279 whole-genome expression profiles from the Genotype-Tissue Expression (GTEx) project. We find sex-biased regulatory network structures in each tissue. Even though most transcription factors (TFs) are not differentially ...[more]
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