Dataset Information

Prognostic value of natural killer cell/T cell ratios for disease activity in multiple sclerosis.

ABSTRACT:

Background and purpose

Natural killer (NK) cells may play a role in multiple sclerosis (MS). Ratios of NK cells to CD4⁺ T cells have been proposed as a biomarker for the therapeutic effect of stem cell transplantation in MS. The objectives here were to explore the relevance of this ratio in MS patients by analysing NK and T cell subsets, as well as their prognostic value for disease activity.

Methods

Baseline peripheral blood mononuclear cells of 50 relapsing-remitting MS patients, participating in our vitamin D supplementation study (SOLARIUM), were analysed with flow cytometry. Disease activity was measured as new magnetic resonance imaging lesions, relapses and mean plasma neurofilament light chain levels after 48 weeks of follow-up.

Results

The proportion of NK cells correlated negatively with CD4⁺ T cells (R = -0.335, p = 0.001) and interleukin 17A (IL-17A⁺ ) CD4⁺ T cells (R = -0.203, p = 0.043). Participants with magnetic resonance imaging activity or relapses displayed lower NK/IL-17A⁺ CD4⁺ T cell ratios (p =0.025 and p = 0.006, respectively). The NK/IL-17A⁺ CD4⁺ T cell ratio correlated negatively with neurofilament light chain levels (R = -0.320, p = 0.050). Vitamin D supplementation did not affect these ratios.

Conclusions

Our data suggest a protective role of an expanded NK cell compartment compared to the CD4⁺ T cell subset fractions in relapsing-remitting MS patients. NK/CD4⁺ T cell ratios may be a prognostic biomarker for disease activity in MS.

SUBMITTER: Mimpen M

PROVIDER: S-EPMC7898592 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Publications

Prognostic value of natural killer cell/T cell ratios for disease activity in multiple sclerosis.

Mimpen Max M Muris Anne-Hilde AH Rolf Linda L Gerlach Oliver O Kuhle Jens J Hupperts Raymond R Smolders Joost J Damoiseaux Jan J

European journal of neurology 20201230 3

<h4>Background and purpose</h4>Natural killer (NK) cells may play a role in multiple sclerosis (MS). Ratios of NK cells to CD4<sup>+</sup> T cells have been proposed as a biomarker for the therapeutic effect of stem cell transplantation in MS. The objectives here were to explore the relevance of this ratio in MS patients by analysing NK and T cell subsets, as well as their prognostic value for disease activity.<h4>Methods</h4>Baseline peripheral blood mononuclear cells of 50 relapsing-remitting ...[more]

PMID: 33326677

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Project description:Objective: Early and accurate diagnosis of multiple sclerosis (MS) remains a clinical challenge. The main objective is to evaluate the diagnostic and prognostic value of the routinely performed immunoglobulin G (IgG) index for MS patients in the Asian population. Methods: A retrospective study was conducted among a cohort of clinically isolated syndrome (CIS) patients in China with known oligoclonal band (OCB) status and IgG index at baseline. We first evaluated the predictive value of IgG index for OCB status. Secondly, the diagnostic utility and prognostic value of IgG index alone were tested. Lastly, we incorporated IgG index into the 2017 McDonald criteria by replacing OCB with either "IgG index or OCB" (modified criteria 1), "IgG index and OCB" (modified criteria 2), or "IgG index" (modified criteria 3). The diagnostic utility of different criteria was calculated and compared. Results: In a CIS cohort in China (n = 105), IgG index > 0.7 forecasted OCB positivity (X 2 = 22.90, P < 0.001). An elevated IgG index was highly prognostic of more clinical relapses [1-year adjusted odds ratio [OR] = 1.32, P = 0.015; 2-years adjusted OR = 1.69, P = 0.013] and Expanded Disability Status Scale worsening (1-year adjusted OR = 1.76, P = 0.040; 2-years adjusted OR = 1.85, P = 0.032). Under the 2017 McDonald criteria (Positive Likelihood Ratio = 1.54, Negative Likelihood Ratio = 0.56), an IgG index > 0.7 in CIS patients increased the likelihood of developing MS within 2 years, either when OCB status was unknown (Positive Likelihood Ratio = 2.11) or with OCB positivity (Positive Likelihood Ratio = 2.11) at baseline; An IgG index ≤ 0.7, along with a negative OCB, helped rule out the MS diagnosis (Negative Likelihood Ratio = 0.53). Conclusions: IgG index > 0.7 predicts OCB positivity at the initial attack of MS and is prognostic of early disease activity. IgG index serves as an easily-obtainable and accurate OCB surrogate for MS diagnosis in the Asian population.

Dataset Information

Prognostic value of natural killer cell/T cell ratios for disease activity in multiple sclerosis.

Background and purpose

Methods

Results

Conclusions

Publications

Prognostic value of natural killer cell/T cell ratios for disease activity in multiple sclerosis.

Similar Datasets

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