Genetic association of BIN1 and GAB2 in Alzheimer's disease: A meta-analysis and systematic review.

ABSTRACT:

Aim

Heredity plays an important role in the pathogenesis of Alzheimer's disease (AD) especially for single-nucleotide polymorphism (SNPs) of susceptible genes, which is one of the significant factors in the pathogenesis of AD. The SNPs of BIN1 rs744373, BIN1 rs7561528 and GAB2 rs2373115 are associated with AD in Asian and white people.

Methods

We included 34 studies with a total of 38 291 patients with AD and 55 538 controls of diverse races from four main databases. We used meta-analysis to obtain I² -values and odds ratios of five genetic models in three SNPs. We carried out analysis of sensitivity, subgroup, publication bias and linkage disequilibrium test.

Results

The forest plots showed the odds ratio value of the three SNPs was >1 in white individuals

SUBMITTER: Hao X 

PROVIDER: S-EPMC7898709 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature