Ontology highlight
ABSTRACT:
SUBMITTER: Kanagaki S
PROVIDER: S-EPMC7898721 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Kanagaki Shuhei S Ikeo Satoshi S Suezawa Takahiro T Yamamoto Yuki Y Seki Masahide M Hirai Toyohiro T Hagiwara Masatoshi M Suzuki Yutaka Y Gotoh Shimpei S
Stem cells (Dayton, Ohio) 20201126 2
Alveologenesis is a developmental step involving the expansion of the lung surface area which is essential for gas exchange. The gas exchange process is mediated by alveolar type I (AT1) cells, which are known to be differentiated from alveolar type II (AT2) or bipotent cells. Due to the difficulty of isolating and culturing primary AT1 cells, the mechanism underlying their differentiation is not completely understood. We performed single-cell RNA sequencing (scRNA-seq) of fibroblast-dependent a ...[more]