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Circulating follicular helper T cells and subsets are associated with immune response to hepatitis B vaccination.

ABSTRACT: Around 5-10% of healthy vaccinees lack or produce an inadequate antibody response following receipt of a standard hepatitis B vaccination regimen. Studying immune response to hepatitis B vaccination could promote researches of immunological events contributing to this poor response. To address this, we investigated follicular helper T (Tfh) cells and firstly demonstrated similar kinetics between circulating Tfh (cTfh) cells and Tfh cells derived from mice spleen after hepatitis B vaccination. And cTfh cells were positively associated with anti-HBs at one week after vaccination (D7). Furthermore, we found PBMCs stimulated by HBsAg showed preferential activation of CXCR3^- Tfh cells subsets in vitro. The expression of transcription factor BCL6 in CD4⁺ T cell significantly differed between D7 and four weeks after vaccination (D28). However, dynamic curve of CD19⁺ B cells tended to rise then fall but no significant trends were observed. Our findings revealed a decrease in cTfh cells and subset skewing contribute to reduced antibody responses in immune response to hepatitis B vaccination, which indicated the importance of Tfh cell in facilitating the optimization of vaccine efficacy.

SUBMITTER: Yin M

PROVIDER: S-EPMC7899680 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Circulating follicular helper T cells and subsets are associated with immune response to hepatitis B vaccination.

Yin Mingjuan M Xiong Yongzhen Y Huang Lingfeng L Liu Gang G Yu Zuwei Z Zhao Yi Y Zhao Jie J Zhang Yan Y Lian Tingyu T Huang Jingxiao J Liang DongMei D Zeng JinMei J Ni Jindong J

Human vaccines & immunotherapeutics 20200702 2

Around 5-10% of healthy vaccinees lack or produce an inadequate antibody response following receipt of a standard hepatitis B vaccination regimen. Studying immune response to hepatitis B vaccination could promote researches of immunological events contributing to this poor response. To address this, we investigated follicular helper T (Tfh) cells and firstly demonstrated similar kinetics between circulating Tfh (cTfh) cells and Tfh cells derived from mice spleen after hepatitis B vaccination. An ...[more]

PMID: 32614645

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Circulating follicular helper T cells and subsets are associated with immune response to hepatitis B vaccination.

Publications

Circulating follicular helper T cells and subsets are associated with immune response to hepatitis B vaccination.

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