Dataset Information

Inflammation and salt in young adults: the African-PREDICT study.

ABSTRACT:

Purpose

Low-grade inflammation and a diet high in salt are both established risk factors for cardiovascular disease. High potassium (K⁺) intake was found to counter increase in blood pressure due to high salt intake and may potentially also have protective anti-inflammatory effects. To better understand these interactions under normal physiological conditions, we investigated the relationships between 22 inflammatory mediators with 24-h urinary K⁺ in young healthy adults stratified by low, medium and high salt intake (salt tertiles). We stratified by ethnicity due to potential salt sensitivity in black populations.

Methods

In 991 healthy black (N?=?457) and white (N?=?534) adults, aged 20-30 years, with complete data for 24-h urinary sodium and K⁺, we analysed blood samples for 22 inflammatory mediators.

Results

We found no differences in inflammatory mediators between low-, mid- and high-sodium tertiles in either the black or white groups. In multivariable-adjusted regression analyses in white adults, we found only in the lowest salt tertile that K⁺ associated negatively with pro-inflammatory mediators, namely interferon gamma, interleukin (IL) -7, IL-12, IL-17A, IL-23 and tumour necrosis factor alpha (all p???0.046). In the black population, we found no independent associations between K⁺ and any inflammatory mediator.

Conclusion

In healthy white adults, 24-h urinary K⁺ associated independently and negatively with specific pro-inflammatory mediators, but only in those with a daily salt intake less than 6.31 g, suggesting K⁺ to play a protective, anti-inflammatory role in a low-sodium environment. No similar associations were found in young healthy black adults.

SUBMITTER: Crouch SH

PROVIDER: S-EPMC7900065 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Publications

Inflammation and salt in young adults: the African-PREDICT study.

Crouch Simone H SH Botha-Le Roux Shani S Delles Christian C Graham Lesley A LA Schutte Aletta E AE

European journal of nutrition 20200603 2

<h4>Purpose</h4>Low-grade inflammation and a diet high in salt are both established risk factors for cardiovascular disease. High potassium (K<sup>+</sup>) intake was found to counter increase in blood pressure due to high salt intake and may potentially also have protective anti-inflammatory effects. To better understand these interactions under normal physiological conditions, we investigated the relationships between 22 inflammatory mediators with 24-h urinary K<sup>+</sup> in young healthy a ...[more]

PMID: 32494865

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Project description:Background The endogenous steroidal inhibitor of sodium-potassium-dependent adenosine triphosphate and natriuretic hormone, marinobufagenin, plays a physiological role in ionic homeostasis. Animal models suggest that elevated marinobufagenin adversely associates with cardiac and renal, structural and functional alterations. It remains uncertain whether marinobufagenin relates to the early stages of target organ damage development, especially in young adults without cardiovascular disease. We therefore explored whether elevated 24-hour urinary marinobufagenin excretion was related to indices of subclinical target organ damage in young healthy adults. Design This cross-sectional study included 711 participants from the African-PREDICT study (black 51%, men 42%, 24.8 ± 3.02 years). Methods We assessed cardiac geometry and function by two-dimensional echocardiography and pulse wave Doppler imaging. 24-Hour urinary marinobufagenin and sodium excretion were measured, and the estimated glomerular filtration rate determined. Results Across marinobufagenin excretion quartiles, left ventricular mass ( P < 0.001), end diastolic volume ( P < 0.001), stroke volume ( P = 0.004) and sodium excretion ( P < 0.001) were higher within the fourth compared with the first quartile. Partial regression analyses indicated that left ventricular mass ( r = 0.08, P = 0.043), end diastolic volume ( r = 0.10, P = 0.010) and stroke volume ( r = 0.09, P = 0.022) were positively related to marinobufagenin excretion. In multivariate-adjusted regression analysis, left ventricular mass associated positively with marinobufagenin excretion only in the highest marinobufagenin excretion quartile (adjusted R2 = 0.20; β = 0.15; P = 0.043). This relationship between left ventricular mass and marinobufagenin excretion was evident in women (adjusted R2 = 0.06; β = 0.127; P = 0.015) but not in men (adjusted R2 = 0.06; β = 0.007; P = 0.92). Conclusions Left ventricular mass positively and independently associates with marinobufagenin excretion in young healthy adults with excessively high marinobufagenin excretion. Women may be more sensitive to the effects of marinobufagenin on early structural cardiac changes.

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Dataset Information

Inflammation and salt in young adults: the African-PREDICT study.

Purpose

Methods

Results

Conclusion

Publications

Inflammation and salt in young adults: the African-PREDICT study.

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