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ABSTRACT: Purpose
Choline is an essential nutrient for fetal and infant growth and development. Parenteral nutrition used in neonatal care lack free choline but contain small amounts of lipid-bound choline in the form of phosphatidylcholine (PC). Here, we examined the longitudinal development of serum free choline and metabolically related compounds betaine and methionine in extremely preterm infants and how the concentrations were affected by the proportion of parenteral fluids the infants received during the first 28 postnatal days (PNDs).Methods
This prospective study included 87 infants born at gestational age (GA)?1H NMR spectroscopy.Results
The median (25th-75th percentile) serum concentrations of free choline, betaine, and methionine were 33.7 (26.2-41.2), 71.2 (53.2-100.8), and 25.6 (16.4-35.3) µM, respectively, at PND 1. The choline concentration decreased rapidly between PND one and PND seven [18.4 (14.1-26.4) µM], and then increased over the next 90 days, though never reaching PND one levels. There was a negative correlation between a high intake of parenteral fluids and serum-free choline.Conclusion
Circulating free choline in extremely preterm infants is negatively affected by the proportion of parenteral fluids administered.Trial registration
ClinicalTrials.gov Identifier NCT02760472, April 29, 2016, retrospectively registered.
SUBMITTER: Nilsson AK
PROVIDER: S-EPMC7900091 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
European journal of nutrition 20200625 2
<h4>Purpose</h4>Choline is an essential nutrient for fetal and infant growth and development. Parenteral nutrition used in neonatal care lack free choline but contain small amounts of lipid-bound choline in the form of phosphatidylcholine (PC). Here, we examined the longitudinal development of serum free choline and metabolically related compounds betaine and methionine in extremely preterm infants and how the concentrations were affected by the proportion of parenteral fluids the infants receiv ...[more]