Ontology highlight
ABSTRACT:
SUBMITTER: Miciaccia M
PROVIDER: S-EPMC7900114 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Miciaccia Morena M Belviso Benny Danilo BD Iaselli Mariaclara M Cingolani Gino G Ferorelli Savina S Cappellari Marianna M Loguercio Polosa Paola P Perrone Maria Grazia MG Caliandro Rocco R Scilimati Antonio A
Scientific reports 20210222 1
The beneficial effects of Cyclooxygenases (COX) inhibitors on human health have been known for thousands of years. Nevertheless, COXs, particularly COX-1, have been linked to a plethora of human diseases such as cancer, heart failure, neurological and neurodegenerative diseases only recently. COXs catalyze the first step in the biosynthesis of prostaglandins (PGs) and are among the most important mediators of inflammation. All published structural work on COX-1 deals with the ovine isoenzyme, wh ...[more]