Ontology highlight
ABSTRACT:
SUBMITTER: Wang R
PROVIDER: S-EPMC7900143 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Wang Rong R Yang Yuchen Y Ye Wei-Wu WW Xiang Jianxing J Chen Songan S Zou Wei-Bin WB Wang Xiao-Jia XJ Chen Tianhui T Cao Wen-Ming WM
Frontiers in oncology 20210209
Endocrine treatment plus CDK4/6 inhibitors have become standard of care for estrogen receptor positive (ER+) breast cancer. Although immune checkpoint inhibitors (ICIs) have shown promising antitumor activity in a variety of cancer types, only limited success has been achieved for metastatic breast cancer (mBC) patients, especially the ER+ subtype, which usually exhibit lower tumor mutation burden (TMB) compared with other subtypes and therefore perceived as immunologically quiescent. Here we pr ...[more]