Ontology highlight
ABSTRACT:
SUBMITTER: Lakshmanan LN
PROVIDER: S-EPMC7900216 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Lakshmanan Lakshmi Narayanan LN Yee Zhuangli Z Halliwell Barry B Gruber Jan J Gunawan Rudiyanto R
iScience 20210204 3
Broad evidence in the literature supports double-strand breaks (DSBs) as initiators of mitochondrial DNA (mtDNA) deletion mutations. While DNA misalignment during DSB repair is commonly proposed as the mechanism by which DSBs cause deletion mutations, details such as the specific DNA repair errors are still lacking. Here, we used DNA hybridization thermodynamics to infer the sequence lengths of mtDNA misalignments that are associated with mtDNA deletions. We gathered and analyzed 9,921 previousl ...[more]