TGF?2 and TGF?3 mediate appropriate context-dependent phenotype of rat valvular interstitial cells.
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ABSTRACT:
SUBMITTER: Wang F
PROVIDER: S-EPMC7900227 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
TGFβ2 and TGFβ3 mediate appropriate context-dependent phenotype of rat valvular interstitial cells.
Wang Faye F Zhang Cindy C Kwagh Jae J Strassle Brian B Li Jinqing J Huang Minxue M Song Yunling Y Lehman Brenda B Westhouse Richard R Palanisamy Kamalavenkatesh K Holenarsipur Vinay K VK Borzilleri Robert R Augustine-Rauch Karen K
iScience 20210203 3
This study focused on characterizing the potential mechanism of valvular toxicity caused by TGFβ receptor inhibitors (TGFβRis) using rat valvular interstitial cells (VICs) to evaluate early biological responses to TGFβR inhibition. Three TGFβRis that achieved similar exposures in the rat were assessed. Two dual TGFβRI/-RII inhibitors caused valvulopathy, whereas a selective TGFβRI inhibitor did not, leading to a hypothesis that TGFβ receptor selectivity may influence the potency of valvular toxi ...[more]
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