Protein Complexes Form a Basis for Complex Hybrid Incompatibility.

ABSTRACT: Proteins are the workhorses of the cell and execute many of their functions by interacting with other proteins forming protein complexes. Multi-protein complexes are an admixture of subunits, change their interaction partners, and modulate their functions and cellular physiology in response to environmental changes. When two species mate, the hybrid offspring are usually inviable or sterile because of large-scale differences in the genetic makeup between the two parents causing incompatible genetic interactions. Such reciprocal-sign epistasis between inter-specific alleles is not limited to incompatible interactions between just one gene pair; and, usually involves multiple genes. Many of these multi-locus incompatibilities show visible defects, only in the presence of all the interactions

SUBMITTER: Swamy KBS 

PROVIDER: S-EPMC7900514 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature