The Role of Genetic Ancestry as a Risk Factor for Primary Open-angle Glaucoma in African Americans.

ABSTRACT:

Purpose

POAG is the leading cause of irreversible blindness in African Americans. In this study, we quantitatively assess the association of autosomal ancestry with POAG risk in a large cohort of self-identified African Americans.

Methods

Subjects recruited to the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study were classified as glaucoma cases or controls by fellowship-trained glaucoma specialists. POAAGG subjects were genotyped using the MEGA Ex array (discovery cohort, n = 3830; replication cohort, n = 2135). Population structure was interrogated using principal component analysis in the context of the 1000 Genomes Project superpopulations.

Results

The majority of POAAGG samples lie on an axis between African and European superpopulations, with

SUBMITTER: Cole BS 

PROVIDER: S-EPMC7900887 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature