The NOTCH-HES-1 axis is involved in promoting Th22 cell differentiation.

ABSTRACT:

Background

NOTCH signaling has been shown to play a role in the production of interleukin-22 (IL-22) by CD4⁺ T cells. Multiple T-helper (Th) cell populations secrete IL-22. Th22 (CD4⁺IL22⁺IFNγ^-IL17A^-) cells are a subgroup of CD4⁺ effector T cells that primarily generate IL-22. The regulatory mechanisms of the NOTCH signaling pathway involved in differentiation of the Th22 cell subset have not been completely elucidated. This study aimed to further explore the involvement of NOTCH signaling in Th22 differentiation.

Methods

In vitro combination of IL-6, IL-23, and tumor necrosis factor-α (TNF-α) treatment with naïve CD4⁺ T cells established the Th22 cell induced model. NOTCH signaling was activated by

SUBMITTER: Zeng C 

PROVIDER: S-EPMC7901075 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature