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Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera.

ABSTRACT: The race to produce vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began when the first sequence was published, and this forms the basis for vaccines currently deployed globally. Independent lineages of SARS-CoV-2 have recently been reported: UK, B.1.1.7; South Africa, B.1.351; and Brazil, P.1. These variants have multiple changes in the immunodominant spike protein that facilitates viral cell entry via the angiotensin-converting enzyme-2 (ACE2) receptor. Mutations in the receptor recognition site on the spike are of great concern for their potential for immune escape. Here, we describe a structure-function analysis of B.1.351 using a large cohort of convalescent and vaccinee serum samples. The receptor-binding domain mutations provide tighter ACE2 binding and widespread escape from monoclonal antibody neutralization largely driven by E484K, although K417N and N501Y act together against some important antibody classes. In a number of cases, it would appear that convalescent and some vaccine serum offers limited protection against this variant.

SUBMITTER: Zhou D

PROVIDER: S-EPMC7901269 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Infection- and vaccine-induced antibody binding and neutralization of the B.1.351 SARS-CoV-2 variant.

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Project description: Not available

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Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity.

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Vaccine breakthrough infection and onward transmission of SARS-CoV-2 Beta (B.1.351) variant, Bavaria, Germany, February to March 2021.

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