Dataset Information

Daily Morning Blue Light Therapy for Post-mTBI Sleep Disruption: Effects on Brain Structure and Function.

ABSTRACT: Background: Mild traumatic brain injuries (mTBIs) are associated with novel or worsened sleep disruption. Several studies indicate that daily morning blue light therapy (BLT) is effective for reducing post-mTBI daytime sleepiness and fatigue. Studies demonstrating changes in brain structure and function following BLT are limited. The present study's purpose is to identify the effect of daily morning BLT on brain structure and functional connectivity and the association between these changes and self-reported change in post-mTBI daytime sleepiness. Methods: A total of 62 individuals recovering from a mTBI were recruited from two US cities to participate in a double-blind placebo-controlled trial. Eligible individuals were randomly assigned to undergo 6 weeks of 30 min daily morning blue or placebo amber light therapy (ALT). Prior to and following treatment all individuals completed a comprehensive battery that included the Epworth Sleepiness Scale as a measure of self-reported daytime sleepiness. All individuals underwent a multimodal neuroimaging battery that included anatomical and resting-state functional magnetic resonance imaging. Atlas-based regional change in gray matter volume (GMV) and region-to-region functional connectivity from baseline to post-treatment were the primary endpoints for this study. Results: After adjusting for pre-treatment GMV, individuals receiving BLT had greater GMV than those receiving amber light in 15 regions of interest, including the right thalamus and bilateral prefrontal and orbitofrontal cortices. Improved daytime sleepiness was associated with greater GMV in 74 ROIs, covering many of the same general regions. Likewise, BLT was associated with increased functional connectivity between the thalamus and both prefrontal and orbitofrontal cortices. Improved daytime sleepiness was associated with increased functional connectivity between attention and cognitive control networks as well as decreased connectivity between visual, motor, and attention networks (all FDR corrected p < 0.05). Conclusions: Following daily morning BLT, moderate to large increases in both gray matter volume and functional connectivity were observed in areas and networks previously associated with both sleep regulation and daytime cognitive function, alertness, and attention. Additionally, these findings were associated with improvements in self-reported daytime sleepiness. Further work is needed to identify the personal characteristics that may selectively identify individuals recovering from a mTBI for whom BLT may be optimally beneficial.

SUBMITTER: Raikes AC

PROVIDER: S-EPMC7901882 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Daily Morning Blue Light Therapy for Post-mTBI Sleep Disruption: Effects on Brain Structure and Function.

Raikes Adam C AC Dailey Natalie S NS Forbeck Brittany B Alkozei Anna A Killgore William D S WDS

Frontiers in neurology 20210205

<b>Background:</b> Mild traumatic brain injuries (mTBIs) are associated with novel or worsened sleep disruption. Several studies indicate that daily morning blue light therapy (BLT) is effective for reducing post-mTBI daytime sleepiness and fatigue. Studies demonstrating changes in brain structure and function following BLT are limited. The present study's purpose is to identify the effect of daily morning BLT on brain structure and functional connectivity and the association between these chang ...[more]

PMID: 33633674

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Project description:BACKGROUND:Recent evidence indicates that disrupted sleep could contribute to the development of Alzheimer's disease by influencing the production and/or clearance of the amyloid-? protein. We set up a case-control study to investigate the association between long-term work-induced sleep disruption, cognitive function, and brain amyloid-? burden. METHODS:Nineteen male maritime pilots (aged 48-60?years) with chronic work-related sleep disruption and a sex-, age-, and education-matched control sample (n?=?16, aged 50-60?years) with normal sleep completed the study. Primary sleep disorders were ruled out with in-lab polysomnography. Additional sleep measurements were obtained at home using actigraphy, sleep-wake logs, and a single-lead EEG device. Cognitive function was assessed with a neuropsychological test battery, sensitive to early symptomatic Alzheimer's disease. Brain amyloid-? burden was assessed in maritime pilots using 18F-flutemetamol amyloid PET-CT. RESULTS:Maritime pilots reported significantly worse sleep quality (Pittsburgh Sleep Quality Index (PSQI)?=?8.8?±?2.9) during work weeks, compared to controls (PSQI?=?3.2?±?1.4; 95% CI 0.01 to 2.57; p?=?0.049). This was confirmed with actigraphy-based sleep efficiency (86% ±?3.8 vs. 89.3% ±?4.3; 95% CI 0.43 to 6.03; p?=?0.03). Home-EEG recordings showed less total sleep time (TST) and deep sleep time (DST) during work weeks compared to rest weeks (TST 318.56 (250.21-352.93) vs. TST 406.17 (340-425.98); p?=?0.001; DST 36.75 (32.30-58.58) vs. DST 51.34 (48.37-69.30); p?=?0.005)). There were no differences in any of the cognitive domains between the groups. For brain amyloid-? levels, mean global cortical standard uptake value ratios of 18F-flutemetamol were all in the normal range (1.009?±?0.059; 95% CI 0.980 to 1.037), confirmed by visual reads. CONCLUSIONS:Capitalizing on the particular work-rest schedule of maritime pilots, this study with a small sample size observed that long-term intermittent sleep disruption had no effects on global brain amyloid-? levels or cognitive function.

Dataset Information

Daily Morning Blue Light Therapy for Post-mTBI Sleep Disruption: Effects on Brain Structure and Function.

Publications

Daily Morning Blue Light Therapy for Post-mTBI Sleep Disruption: Effects on Brain Structure and Function.

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