Unknown

Dataset Information

0

Neutrophil calprotectin identifies severe pulmonary disease in COVID-19.


ABSTRACT: Severe cases of coronavirus disease 2019 (COVID-19) are regularly complicated by respiratory failure. Although it has been suggested that elevated levels of blood neutrophils associate with worsening oxygenation in COVID-19, it is unknown whether neutrophils are drivers of the thrombo-inflammatory storm or simple bystanders. To better understand the potential role of neutrophils in COVID-19, we measured levels of the neutrophil activation marker S100A8/A9 (calprotectin) in hospitalized patients and determined its relationship to severity of illness and respiratory status. Patients with COVID-19 (n = 172) had markedly elevated levels of calprotectin in their blood. Calprotectin tracked with other acute phase reactants including C-reactive protein, ferritin, lactate dehydrogenase, and absolute neutrophil count, but was superior in identifying patients requiring mechanical ventilation. In longitudinal samples, calprotectin rose as oxygenation worsened. When tested on day 1 or 2 of hospitalization (n = 94 patients), calprotectin levels were significantly higher in patients who progressed to severe COVID-19 requiring mechanical ventilation (8039 ± 7031 ng/ml, n = 32) as compared to those who remained free of intubation (3365 ± 3146, P < 0.0001). In summary, serum calprotectin levels track closely with current and future COVID-19 severity, implicating neutrophils as potential perpetuators of inflammation and respiratory compromise in COVID-19.

SUBMITTER: Shi H 

PROVIDER: S-EPMC7902293 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

2024-05-05 | GSE236030 | GEO
2024-05-05 | GSE237180 | GEO
2024-05-05 | GSE237109 | GEO
| S-EPMC8039116 | biostudies-literature
| S-BSST416 | biostudies-other
| S-EPMC7405878 | biostudies-literature
2020-12-31 | E-MTAB-9721 | biostudies-arrayexpress
| S-SCDT-EMM-2020-13038 | biostudies-other
| S-EPMC8556860 | biostudies-literature
2023-02-14 | ST002477 | MetabolomicsWorkbench