Identification of immune-related lncRNAs to improve the prognosis prediction for patients with papillary thyroid cancer.

ABSTRACT: To identify immune-related long non-coding RNAs (lncRNAs) in papillary thyroid cancer (PTC). The Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases were used to obtain the gene expression profile. Immune-related lncRNAs were screened from the Molecular Signatures Database v4.0 (MsigDB). We performed a survival analysis of critical lncRNAs. Further, the function of prognostic lncRNAs was inferred using the Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) to clarify the possible mechanisms underlying their predictive ability. The assessment was performed in clinical samples and PTC cells. We obtained 4 immune-related lncRNAs, 15 microRNAs (miRNAs), and 375 mRNAs as the key mediators in the pathophysiological processes of PTC fr

SUBMITTER: Li Z 

PROVIDER: S-EPMC7902395 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature