Ontology highlight
ABSTRACT:
SUBMITTER: Chang Z
PROVIDER: S-EPMC7902613 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Chang Zongliang Z Qin Weibing W Zheng Huili H Schegg Kathleen K Han Lu L Liu Xiaohua X Wang Yue Y Wang Zhuqing Z McSwiggin Hayden H Peng Hongying H Yuan Shuiqiao S Wu Jiabao J Wang Yongxia Y Zhu Shenghui S Jiang Yanjia Y Nie Hua H Tang Yuan Y Zhou Yu Y Hitchcock Michael J M MJM Tang Yunge Y Yan Wei W
Nature communications 20210223 1
There are no non-hormonal male contraceptives currently on the market despite decades of efforts toward the development of "male pills". Here, we report that triptonide, a natural compound purified from the Chinese herb Tripterygium Wilfordii Hook F displays reversible male contraceptive effects in both mice and monkeys. Single daily oral doses of triptonide induces deformed sperm with minimal or no forward motility (close to 100% penetrance) and consequently male infertility in 3-4 and 5-6 week ...[more]