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Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer.

ABSTRACT: Optoacoustic imaging is a new biomedical imaging technology with clear benefits over traditional optical imaging and ultrasound. While the imaging technology has improved since its initial development, the creation of dedicated contrast agents for optoacoustic imaging has been stagnant. Current exploration of contrast agents has been limited to standard commercial dyes that have already been established in optical imaging applications. While some of these compounds have demonstrated utility in optoacoustic imaging, they are far from optimal and there is a need for contrast agents with tailored optoacoustic properties. The synthesis, encapsulation within tumor targeting silica nanoparticles and applications in in vivo tumor imaging of optoacoustic contrast agents are reported.

SUBMITTER: Laramie MD

PROVIDER: S-EPMC7902650 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer.

Laramie Matthew D MD Fouts Benjamin L BL MacCuaig William M WM Buabeng Emmanuel E Jones Meredith A MA Mukherjee Priyabrata P Behkam Bahareh B McNally Lacey R LR Henary Maged M

Scientific reports 20210223 1

Optoacoustic imaging is a new biomedical imaging technology with clear benefits over traditional optical imaging and ultrasound. While the imaging technology has improved since its initial development, the creation of dedicated contrast agents for optoacoustic imaging has been stagnant. Current exploration of contrast agents has been limited to standard commercial dyes that have already been established in optical imaging applications. While some of these compounds have demonstrated utility in o ...[more]

PMID: 33623069

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